About the Lab
Yuval Rinkevich

Email:   yuval.rinkevich@cimrbj.ac.cn

Administrative contact: hejunqi@cimrbj.ac.cn;kangke@cimrbj.ac.cn

Mobile: +86 136 8125 3597

Institute Director, Institute for Regenerative Biology and Medicine (IRBM), Chinese Institutes for Medical Research (CIMR), Beijing, China

Chair Professor, Capital Medical University, Beijing, China  

Education and Experience
Full Professor, Capital Medical University, Beijing, China
Institute Director, Institute for Regenerative Biology and Medicine (IRBM), CIMR, Beijing, China
Institute Director, Institute for Regenerative Biology and Medicine (IRBM), Helmholtz Center Munich, Germany
Tenured Principal Investigator, Institute for Lung Biology and Disease; Helmholtz Center Munich, Germany
PI of Research Group, Institute for Lung Biology and Disease; Helmholtz Center Munich, Germany 
Basic Life Science Research Associate, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, (Prof. Irving L. Weissman, Advisor)
Post doctorate, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University (Prof. Irving L. Weissman, Advisor)
Doctorate in Biology (PhD), Thesis title: Cellular and Molecular Mechanisms Underlying Whole Body Regeneration in the Colonial Ascidian Botrylloides leachi, Israel Institute of Technology, Haifa, Israel (Dr. Ram Reshef, Advisor)
Master of Science (MSc), Thesis title: Determination and Differentiation of Muscle Satellite Cells, Israel Institute of Technology, Haifa, Israel (Dr. Ram Reshef, Advisor)
Bachelor of Science (BSc), Faculty of Life Sciences, Tel-Aviv University, Israel
Key publications
1

(2025)Kadri S, Fischer A, Mück-Häusl M, Han W, Kadri A, Lin Y, Yang L, Hu S, Ye H, Ramesh P, Ansari M, Schiller H, Hans-Günther M, Rinkevich Y. (2025). A mesothelial differentiation gateway drives fibrosis (2025). Nature Communications. doi: https://doi.org/10.1038/s41467-025-63990-2. 

(2025)Rinkevich, Y. & Baruch Rinkevich (2025), From Fragment to Form: Whole-Body Regeneration in a Model, Urochordate. NPJ Regenerative Medicine. 10, Article number: 36 (2025) doi: https://doi.org/10.1038/s41536-025-00423-0  

(2025)Torregrossa, M., Davies, L., Machens, H.-G., Simon, J.C., Franz, S. & Rinkevich, Y. (2025). Effects of embryonic origin, tissue cues and pathological signals on fibroblast diversity in humans. Nature Cell Biology, doi: 10.1038/s41556-025-01638-5. 

(2025)Fischer, A., Han, W., Hu, S., Mück-Häusl, M., Wannemacher, J., Kadri, S., Lin, Y., Dai, R., Christ, S., Su, Y., Dasgupta, B., Sardogan, A., Deisenhofer, C., Dutta, S., Kadri, A., Güney, T.G., Correa-Gallegos, D., Mayr, C.H., Hatz, R., Stoleriu, M.G., Lindner, M., Hilgendorff, A., Adler, H., Machens, H.-G., Schiller, H.B., Hauck, S.M. &Rinkevich, Y. (2025). Targeting pleuro-alveolar junctions reverses lung fibrosis in mice. Nature Communications, 16(1), 173. doi: 10.1038/s41467-024-55596-x.

(2024)CZ,CZ,Rinkevich,Y(2024),Tissue fluidity:biophysical shape-shifting for regeneration,SignalTransduct Target Ther.2024Nov26;9(1):329.doi:https://doi.org/10.1038/s41392-024-02068-9

(2024)Jiang D,Machens HG,Rinkevich,Y,Sensory neurons:unveiling the symphony of wound healing,SignalTransduct Target Ther.2024 Jul 24;9(1):177.doi:https://doi.org/10.1038/s41392-024-01880-7

(2023)CorreaGallegos,D.Ye,H.,Dasgupta,B.,Sardogan,A.,Kadri,S.,Kandi,R.,Dai,R.,Lin,Y.,Kopplin,R.Shenai,D.S.,Wannemacher,J.,Ichijo,R.,Jiang,D.Strunz,M.,Ansari,M.Angelidis,1.,Schiller,H.B.,Volz,T.,Machens,H.-G.&Rinkevich,Y.(2023).CD201+fascia progenitors choreograph injury repair.Nature,623(7988),792-802.doi:https://doi.org/10.1038/s41586-023-06725-x 

(2023)Rajendran V,Ramesh P,DaiR,Kalgudde Gopal S,Ye H,Machens HG,Adler H,Jiang D,Rinkevich,Y,Therapeutic Silencing of pl20 in Fascia Fibroblasts Ameliorates Tissue Repair.JInvest Dermatol.2023May;143(5):854-863.e4.Epub 2022 Nov 26.doi:https://doi.org/10.1016/j.jid.2022.10.018 

(2023)Kalgudde Gopal,S.,Dai,R.,Stefanska,A.M.,Ansari,M.Zhao,J.,Ramesh,P.,Bagnoli,J.W.,Correa-Gallegos,D.Lin,Y.,Christ,S.,Angelidis,1.,Lupperger,V.,Marr,C.,Davies,LC.,Enard,W.,Machens,H.-G.,Schiller,H.B.,Jiang,D.and Rinkevich,Y.,2023.Wound infiltrating adipocytes are not myofibroblasts.Nature Communications,14,Article number:3020.doi:https://doi.org/10.1038/s41467-023-38591-6

(2023)Correa-Gallegos, D., Ye, H., Dasgupta, B., Sardogan, A., Kadri, S., Kandi, R., Dai, R., Lin, Y., Kopplin, R., Shenai, D.S., Wannemacher, J., Ichijo, R., Jiang, D., Strunz, M., Ansari, M., Angelidis, I., Schiller, H.B., Volz, T., Machens, H.-G. & Rinkevich, Y. (2023). CD201⁺ fascia progenitors choreograph injury repair. Nature,623(7988), 792–802. doi: 10.1038/s41586-023-06725-x.

(2023)Kalgudde Gopal, S., Dai, R., Stefanska, A.M., Ansari, M., Zhao, J., Ramesh, P., Bagnoli, J.W., Correa-Gallegos, D., Lin, Y., Christ, S., Angelidis, I., Lupperger, V., Marr, C., Davies, L.C., Enard, W., Machens, H.-G., Schiller, H.B., Jiang, D. and Rinkevich, Y., 2023. Wound infiltrating adipocytes are not myofibroblasts. Nature Communications, 14, Article number: 3020. https://doi.org/10.1038/s41467-023-38753-1

(2022)Correa-Gallegos D,Rinkevich,Y,Cutting into wound repair,FEBSJ.2022 Sep;289(17):5034-5048.Epub2021 Jun 23.doi:https://doi.org/10.11/febs.16078

(2022)Correa-Gallegos D,Machens HG,Rinkevich,Y,States and Fates of Skin Fibroblasts Revealed throughChromatin Accessibility,JInvest Dermatol.2022 Jul;142(7):1767-1770.Epub 2022 Feb 18.doi:https://doi.org/10.1016/ijid.2021.12.035

(2022)Fischer,A.,Wannemacher,J.,Christ,S.,Koopmans,T.,Kadri,S.,Zhao,J.,Gouda,M.,Ye,H.,Mück- Häusl,M,Krenn,P.W.,Machens,H.-G.Fassler,R.,Neumann,P.-A.,Hauck,S.M.&Rinkevich,Y.(2022).Neutrophils directpreexisting matrix to initiate repair in damaged tissues.Nature Immunology,23,1406-1419.doi:https://doi.org/10.1038/s41590-022-01166-6

(2022)Fischer, A., Wannemacher, J., Christ, S., Koopmans, T., Kadri, S., Zhao, J., Gouda, M., Ye, H., Mück-Häusl, M., Krenn, P.W., Machens, H.-G., Fässler, R., Neumann, P.-A., Hauck, S.M. & Rinkevich, Y. (2022). Neutrophils direct preexisting matrix to initiate repair in damaged tissues. Nature Immunology, 23, 1406–1419. doi: 10.1038/s41590-022-01166-6.

(2021)Jiang D,Rinkevich,Y,Converting fibroblastic fates leads to wound healing without scar,SignalTransduct Target Ther.2021 Sep 1;6(1):332.doi:https://doi.org/10.1038/s41392-021-00738-6

(2021)Correa-Gallegos D,Jiang D,Rinkevich,Y,Fibroblasts as confederates of the immune system,ImmunolRev.2021 Jul;302(1):147-162.Epub 2021 May 25.doi:https://doi.org/10.11/imr.12972

(2021)Wan L,Jiang D,Correa-Gallegos D,Ramesh P,Zhao J,Ye H,Zhu s,Wannemacher J,VolzT,Rinkevich,Y,Connexin43 gap junction drives fascia mobilization and repair of deep skin wounds,Matrix Biol.2021Mar;97:58-71.Epub 2021 Jan 27.doi:https://doi.org/10.1016/j.matbio.2021.01.005

(2020)Jiang D,Christ S,Correa-Gallegos D,Ramesh P,Kalgudde Gopas,Wannemacher J,Mayr C,Lupperger v,Yu Q,Ye H,Mück-Häusl M,Rajendran V,Wan L,Liu J,Mirastschijski U,Volz T,Marr C, Schiller H,Rinkevich,Y(2020)Injury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin,Nature Communications 11,5653.doi:https://doi.org/10.1038/s41467-020-19425-1

(2020)Fischer A,Koopmans T,Ramesh P,Christ S,Strunz M,Aichler M,Feuchtinger A,Walch A,Ansari M,Theis FJ,Schorpp K,Hadian K,Neumann PA,Schiller HB,Rinkevich,Y(2020)Post-surgical adhesions are triggeredby calcium-dependent membrane bridges between mesothelial surfaces,Nature Communications 11,3068.doi:https://doi.org/10.1038/s41467-020-16893-3

(2020)Jiang D, Christ S, Correa-Gallegos D, Ramesh P, Kalgudde Gopa S, Wannemacher J, Mayr C, Lupperger V, Yu Q, Ye H, Mück-Häusl M, Rajendran V, Wan L, Liu J, Mirastschijski U, Volz T, Marr C, Schiller H, Rinkevich Y (2020) Fascia fibroblasts swarm to drive scar formation through N-cadherin, Nature Communications 11, 5653

(2020)Fischer A, Koopmans T, Ramesh P, Christ S, Strunz M, Aichler M, Feuchtinger A, Walch A, Ansari M, Theis FJ, Schorpp K, Hadian K, Neumann P A, Schiller HB, Rinkevich Y (2020) Post-surgical adhesions are caused by membrane bridges and fusions between mesothelial surfaces, Nature Communications 11, 3068 

(2019)Correa-Gallegos D,Jiang D,Christ S,Ramesh P,Ye H,Wannemacher J,Kalgudde Gopal S,YuQ,AichlerM,Walch A,MirastschijskiU,Volz T,Rinkevich,Y(2019)Patch repair of deep wounds by mobilized fascia,Nature 576,287-292.doi:https://doi.org/10.1038/s41586-019-1794-y

(2019)Correa-Gallegos D, Jiang D, Christ S, Ramesh P, Ye H, Wannemacher J, Kalgudde Gopal S, Yu Q, Aichler M,Walch A, Mirastschijski U, Volz T, Rinkevich Y (2019) Patch repair of deep wounds by mobilized fascia,  Nature 576, 287-292 

(2018)Jiang D,Correa-Gallegos D,Christ s,Stefanska A,Liu J,Ramesh P,Rajendran V,Wagner D,Rinkevich,Y(2018)Two succeeding fibroblastic lineages drive dermal development and the transition fromregeneration to scarring,Nature Cell Biology 20:422-431.doi:https://doi.org/10.1038/s41556-018-0073-8

(2018)Tsai JM,Sinha R,Seita J,Fernhoff N,Christ S,Koopmans T,Krampitz GW,McKenna KM,Xing L,Shoham M,10.McCracken M,Joubert LM,Gordon SR,Poux N,Wernig G,Norton JA,Sandholzer M,Sales J,Weissman IL,Rinkevich,Y(2018)surgical adhesions in mice are derived from mesothelial cells and can be targeted byantibodies against mesothelialmarkers,Science Translational Medicine 10(469).doi:https://doi.org/10.1126/scitranslmed.aan6735

(2018)Rinkevich Y(2018) Surgical adhesions in mice are derived from mesothelial cells and can be targeted by antibodies against mesothelial markers, Science Translational Medicine 10(469)

(2018)Jiang D, Correa-Gallegos D, Christ S, Stefanska A, Liu J, Ramesh P, Rajendran V, Wagner D, Rinkevich Y (2018) Two succeeding fibroblastic lineages drive dermal development and the transition from regeneration to scarring, Nature Cell Biology 20:422-431

(2015)Rinkevich Y,Walmsley GG, Hu MS, Maan ZN, Newman AM, Drukker M, Lorenz PH, Weissman IL, Longaker MT  (2015) Identification and Targeted inhibition of a Dermal Lineage Responsible for Scarring and Cancer Stroma Science 348:420-431

(2015)Romagnani P, Rinkevich Y, Dekel B (2015) Lineage Tracing Methods to Study Kidney Injury and Regeneration, their Limitations and Advantages, Nature Reviews Nephrology 11:420-431

Tsai JM, Sinha R,  Seita J, Fernhoff N, Christ S, Koopmans T, Krampitz GW,  McKenna KM, Xing L, Shoham M, 10. McCracken M, Joubert LM, Gordon SR, Poux N, Wernig G, Norton JA, Sandholzer M, Sales J, Weissman IL