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About the Lab
Lab Overview Principal Investigator Location
Regenerative Medicine
Regenerative medicine represents the future of medicine, aiming to revolutionize treatments for human disease, trauma, and aging. This interdisciplinary field bridges fundamental biological research and clinical applications to better understand and address the underlying mechanisms of tissue damage and repair.
Tissue Regeneration
At the Rinkevich Lab, our focus is on uncovering the core cellular and molecular principles of tissue and organ regeneration. By delving into these fundamental processes, we aim to develop innovative therapeutic strategies to enhance tissue repair and regeneration in clinical settings.
Advanced Techniques
We employ cutting-edge tools and methodologies to tackle pressing questions in regenerative biology. These include:
Mouse Genetics
Leveraging sophisticated multicolor ‘Rainbow’ and Tetrachimera mouse models.
Surgical Models
Establishing specialized rodent surgery techniques to simulate tissue damage and repair.
Single-Cell Omics & Flow Cytometry
Decoding cellular diversity and interactions at the single-cell level.
Molecular and Cellular Approaches
Studying the dynamics of stem cells in tissue regeneration and the mechanisms of maladaptive wound repair, including chronic wounds and organ fibrosis.
Focus on Lung Fibrosis
One of our key research areas involves exploring the embryonic origins of fibroblasts and their roles in tissue repair. Utilizing live in-vivo imaging and advanced wound healing models in both fetal and adult mice, we aim to unravel the mechanisms underlying lung fibrosis and its progression.
Institute Synergy
The Institute for Regenerative Biology and Medicine (IRBM) at the Chinese Institutes for Medical Research (CIMR) fosters seamless integration of basic and applied research. Our scientific endeavors include:
Investigating tissue repair and regeneration in animal models.
Unveiling the cellular and molecular mechanisms that drive repair and regeneration.
Exploring the pathological processes of fibrotic diseases, including scarring, fibrosis, sclerosis, adhesions, and chronic wounds.