Yingxi received her Ph.D. degree in Medical Genetics from Xiang-Ya School of Medicine, Central South University, China. She concentrated on human genetic disease diagnosis and research during her Ph.D. training, in conjunction with many years of experience in clinical diagnosis with a focus on diseases involving multiple organ systems. She has confirmed or corrected the clinical diagnosis of patients with Marfan syndrome and its related disorders and investigated the linkage of the causative genes and the pathologic mechanism.Then she joined Weill Cornell Medicine, Cornell University in New York City as a postdoc and started her research on cardiovascular development and regeneration. Her study focused on dissecting the mechanisms of epicardium-guided heart regeneration. In 2022, she was awarded the Lisa and Sanford B. Ehrenkranz Young Scientist in the recognition of her work on cardiac regeneration.Yingxi currently is an Associate Researcher in the Rinkevich lab and responsible for conducting projects that focus primarily on cellular and molecular mechanisms of organ/tissue development and regeneration, which has high translation potential to help with human disease.
Cao, Y., Xia, Y., Balowski, J. J., Ou, J., Song, L., Safi, A., Curtis, T., Crawford, G. E., Poss, K. D., & Cao, J. (2022). Identification of enhancer regulatory elements that direct epicardial gene expression during zebrafish heart regeneration. Development (Cambridge, England), 149(4), dev200133. https://doi.org/10.1242/dev.200133
Cao, Y., Duca, S., & Cao, J. (2020). Epicardium in Heart Development. Cold Spring Harbor perspectives in biology, 12(2), a037192. https://doi.org/10.1101/cshperspect.a037192
Cao, Y., & Cao, J. (2018). Covering and Re-Covering the Heart: Development and Regeneration of the Epicardium. Journal of cardiovascular development and disease, 6(1), 3. https://doi.org/10.3390/jcdd6010003
Cao, Y., Tan, H., Li, Z., Linpeng, S., Long, X., Liang, D., & Wu, L. (2018). Three Novel Mutations in FBN1 and TGFBR2 in Patients with the Syndromic Form of Thoracic Aortic Aneurysms and Dissections. International heart journal, 59(5), 1059–1068. https://doi.org/10.1536/ihj.18-046
Duca, S., Xia, Y., Abd Elmagid, L., Bakis, I., Qiu, M., Cao, Y., Guo, Y., Eichenbaum, J. V., McCain, M. L., Kang, J., Harrison, M. R. M., & Cao, J. (2024). Differential vegfc expression dictates lymphatic response during zebrafish heart development and regeneration. Development (Cambridge, England), 151(22), dev202947. https://doi.org/10.1242/dev.202947
Xia, Y., Duca, S., Perder, B., Dündar, F., Zumbo, P., Qiu, M., Yao, J., Cao, Y., Harrison, M. R. M., Zangi, L., Betel, D., & Cao, J. (2022). Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration. Nature communications, 13(1), 7704. https://doi.org/10.1038/s41467-022-35433-9
Yang, C., Linpeng, S., Cao, Y., & Wu, L. (2019). Identification of six novel mutations in five infants with suspected maple syrup urine disease based on blood and urine metabolism screening. Gene, 710, 9–16. https://doi.org/10.1016/j.gene.2019.04.086
Linpeng, S., Liu, J., Pan, J., Cao, Y., Teng, Y., Liang, D., Li, Z., & Wu, L. (2018). Diagnosis of Joubert Syndrome 10 in a Fetus with Suspected Dandy-Walker Variant by WES: A Novel Splicing Mutation in OFD1. BioMed research international, 2018, 4032543. https://doi.org/10.1155/2018/4032543
Zhang, R., Linpeng, S., Li, Z., Cao, Y., Tan, H., Liang, D., & Wu, L. (2018). Deficiency in GnRH receptor trafficking due to a novel homozygous mutation causes idiopathic hypogonadotropic hypogonadism in three prepubertal siblings. Gene, 669, 42–46. https://doi.org/10.1016/j.gene.2018.05.050
Long, X., Huang, Y., Tan, H., Li, Z., Zhang, R., Linpeng, S., Lv, W., Cao, Y., Li, H., Liang, D., & Wu, L. (2018). Identification of a novel MIP frameshift mutation associated with congenital cataract in a Chinese family by whole-exome sequencing and functional analysis. Eye (London, England), 32(8), 1359–1364. https://doi.org/10.1038/s41433-018-0084-5
Ma, R., Deng, L., Xia, Y., Wei, X., Cao, Y., Guo, R., Zhang, R., Guo, J., Liang, D., & Wu, L. (2017). A clear bias in parental origin of de novo pathogenic CNVs related to intellectual disability, developmental delay and multiple congenital anomalies. Scientific reports, 7, 44446. https://doi.org/10.1038/srep44446
