I am Zuobao Lin, originally from Xinyang City, Henan Province, China. My passion for biology began in high school and led me to pursue a Ph.D. in stem cell and developmental biology through a joint program between Westlake University and Fudan University, which I completed in June 2025.My research focuses on stem cells in tissue homeostasis and regeneration. During my doctoral studies, I used in vivo lineage tracing to dissect the hierarchical organization of mammary stem cells. I discovered that bipotent and unipotent mammary stem cells coexist and cooperatively maintain long-term tissue homeostasis—resolving a longstanding debate about epithelial lineage potential in postnatal mammary development.I am now eager to extend my research to skin wound healing, with a particular interest in how fascia fibroblasts orchestrate regeneration and tissue repair. I aim to uncover the cellular and molecular mechanisms by which these cells drive scar formation, extracellular matrix remodeling, and regenerative outcomes.My expertise lies in genetic lineage tracing, organoid culture, and the molecular regulation of tissue development, homeostasis, and repair.
Lin, Z. B., Guo, Y. J., Bai, H. R., Liu, X. Q., Lin, M. Z., Zhang, Y., Tang, R. L., Hu, T. E., Yu, L. L., Wang, C. H., & Cai, S. (2025). Distinct mammary stem cells orchestrate long-term homeostasis of adult mammary gland. Cell Discovery, 11, 39. https://doi.org/10.1038/s41421-025-00794-0
Lin, Z. B., Wang, C. H., Bai, H. R., Zhang, Y., Lin, M. Z., Liu, X. Q., Hu, T. E., & Meng, Y. (2025). Mycn is essential for pubertal mammary gland development and promotes the activation of Bcl11b-maintained quiescent stem cells. Cells, 14(16), 1239. https://doi.org/10.3390/cells14161239
Yuan, L., Xie, S. F., Bai, H. R., Liu, X. Q., Cai, P., Lu, J., Wang, C. H., Lin, Z. B., Li, S. Y., & Cai, S. (2023). Reconstruction of dynamic mammary mini gland in vitro for normal physiology and oncogenesis. Nature Methods, 20(12), 2021-2033. https://doi.org/10.1038/s41592-023-02039-y
Cao, J., Lin, Z. B., Tong, M. H., Zhang, Y. L., Li, Y. P., & Zhou, Y. C. (2020). Mechanistic target of rapamycin kinase (Mtor) is required for spermatogonial proliferation and differentiation in mice. Asian Journal of Andrology, 22(2), 169–176. https://doi.org/10.4103/aja.aja_14_19
