I am a biologist with a background in animal sciences (B.Sc.Agr.), marine biology (M.Sc.), and evolutionary biology (Ph.D.). For over a decade, my research has focused on the colonial invertebrate Botryllus schlosseri, a powerful model organism for investigating fundamental processes, including aging, regeneration, rejuvenation, stem cell biology, immunology, and chimerism.My work has contributed insights across several levels of biology. I identified and characterized the “Orshina Rhythm,” a recurring pattern of aging and rejuvenation tied to reproduction and fission events in Botryllus. I demonstrated that the stress protein mortalin orchestrates cyclic aging and regeneration at the module level, regulating growth and colonial development through the blastogenic cycle. I also co-authored a book chapter presenting the life history, biology, and anatomy of Botryllus, in which it is discussed as an emerging model organism with significant potential for both basic biology and regenerative medicine.In addition, I investigate aging theories in practice, focusing on the role of cellular waste as a contributor to aging, particularly lipofuscin, which is studied as a marker and potential trigger of module senescence. I am currently characterizing gene expression programs that govern cycles of aging, rejuvenation, and regeneration, and I also explore ecological and evolutionary strategies such as chimerism, which enhance resilience under stress.By integrating long-term organismal tracking with molecular, cellular, and histological approaches, I aim to uncover unifying principles of aging and regeneration, and to translate these discoveries into insights relevant for medical regeneration.
Book chapter- Ben-Hamo, O., & Rinkevich, B. (2021). Botryllus schlosseri—A model colonial species in basic and applied studies. In Handbook of marine model organisms in experimental biology (pp. 385-402). CRC Press.
Cima, F., Burighel, P., Brunelli, N., Ben-Hamo, O., & Ballarin, L. (2025). Phagocyte dynamics in the blastogenetic cycle of the colonial ascidian Botryllus schlosseri: Cell senescence, segregation and clearance after efferocytosis. Developmental & Comparative Immunology, 162, 105271.
Ben-Hamo, O., Izhaki, I., Ben-Shlomo, R., & Rinkevich, B. (2023). The novel Orshina Rhythm in a colonial urochordate signifies the display of recurrent aging/rejuvenation sequels. Scientific Reports, 13(1), 9788.
Ben-Hamo, O., Izhaki, I., Ben-Shlomo, R., & Rinkevich, B. (2022). Fission in a colonial marine invertebrate signifies unique life history strategies rather than being a demographic trait. Scientific Reports, 12(1), 15117.
Rinkevich, B., Ballarin, L., Martinez, P., Somorjai, I., Ben‐Hamo, O., Borisenko, I., ... & Hobmayer, B. (2022). A pan‐metazoan concept for adult stem cells: the wobbling Penrose landscape. Biological Reviews, 97(1), 299-325.
Ben-Hamo, O., Rosner, A., Rabinowitz, C., Oren, M., & Rinkevich, B. (2018). Coupling astogenic aging in the colonial tunicate Botryllus schlosseri with the stress protein mortalin. Developmental Biology, 433(1), 33-46.