Chase received his bachelor’s degree from Xiangya School of Medicine, Central South University, China and master’s degree from Nanjing Medical University, China. His research has focused on the pathogenesis and treatment of various liver diseases, with a particular emphasis on the roles of hepatocytes and immune cells in the development and resolution of liver fibrosis.
Zhigang Lei#, Rui Tang#, Yu Wu#, Chenxu Mao, Weijie Xue, Junyao Shen, Jiaojiao Yu, Xiaohong Wang, Xin Qi, Chuan Wei, Lei Xu, Jifeng Zhu, Yalin Li, Xiujun Zhang, Chunyan Ye, Xiaojun Chen1*, Xiaojun Yang*, Sha Zhou*, and Chuan Su*. TGF-β1 induces PD-1 expression in macrophages through SMAD3-STAT3 cooperative signaling in chronic inflammation. JCI Insight, 2024, 9(7):e165544.
Zhigang Lei†, Yu Wu†, Weijie Xue†, Dongmei Zhu†, Junyao Shen, Chenxu Mao, Ziling Wang, Chuanhong Huang, Yuxin Zhang, Jifeng Zhu, Lei Xu, Yalin Li, Xiujun Zhang, Shouguo Liu, Xiaojun Chen*, Chunyan Ye*, Sha Zhou*, Chuan Su*. Epigenetic repression of hepatocyte FoxO1 disrupts local immune homeostasis and promotes liver inflammation. Hepatology, 2025, doi: 10.1097/HEP.0000000000001590.
Zhigang Lei, Jiaojiao Yu, Yu Wu, Junyao Shen, Shibo Lin, Weijie Xue, Chenxu Mao, Rui Tang, Haoran Sun, Xin Qi, Xiaohong Wang, Lei Xu, Chuan Wei, Xiaowei Wang, Hongbing Chen, Ping Hao, Wen Yin, Jifeng Zhu, Yalin Li, Yi Wu, Shouguo Liu, Hui Liang, Xiaojun Chen*, Chuan Su*, and Sha Zhou*. CD1d Protects against Hepatocyte Apoptosis in Nonalcoholic Steatohepatitis. Journal of Hepatology. 2024, 80(2):194-208.
